3t6a

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Structure of the C-terminal domain of BCAR3

Structural highlights

3t6a is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:POG, UNX
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BCAR3_HUMAN May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.[1]

References

  1. ↑ van Agthoven T, van Agthoven TL, Dekker A, van der Spek PJ, Vreede L, Dorssers LC. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J. 1998 May 15;17(10):2799-808. PMID:9582273 doi:http://dx.doi.org/10.1093/emboj/17.10.2799

Contents


PDB ID 3t6a

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OCA

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