3tip

Structural highlights

Function

SASG_STAA8 Promotes adhesion of bacterial cells to human squamous nasal epithelial cells, a phenomenon which is likely to be important in nasal colonization. Forms short, extremely dense and thin fibrils all over the bacterial surface. Does not bind to either buccal cells or non-differentiated keratinocytes. Promotes cellular aggregation leading to biofilm formation.^{[1] [2]}

References

1. ↑ Roche FM, Meehan M, Foster TJ. The Staphylococcus aureus surface protein SasG and its homologues promote bacterial adherence to human desquamated nasal epithelial cells. Microbiology. 2003 Oct;149(Pt 10):2759-67. PMID:14523109
2. ↑ Corrigan RM, Rigby D, Handley P, Foster TJ. The role of Staphylococcus aureus surface protein SasG in adherence and biofilm formation. Microbiology. 2007 Aug;153(Pt 8):2435-46. PMID:17660408 doi:http://dx.doi.org/10.1099/mic.0.2007/006676-0