3x38

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Crystal structure of the C-terminal domain of Sld7

Structural highlights

3x38 is a 4 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.801Å
Ligands:GOL, SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SLD7_YEAST Required for the proper function of SLD3 at the initiation of DNA replication. Binds to SLD3 and reduces its affinity for CDC45, a component of the replication fork. Required for mitochondrial morphology.[1] [2]

References

  1. ↑ Altmann K, Westermann B. Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Mol Biol Cell. 2005 Nov;16(11):5410-7. Epub 2005 Aug 31. PMID:16135527 doi:http://dx.doi.org/10.1091/mbc.E05-07-0678
  2. ↑ Tanaka T, Umemori T, Endo S, Muramatsu S, Kanemaki M, Kamimura Y, Obuse C, Araki H. Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J. 2011 May 18;30(10):2019-30. doi: 10.1038/emboj.2011.115. Epub 2011 Apr, 12. PMID:21487389 doi:http://dx.doi.org/10.1038/emboj.2011.115

Contents


PDB ID 3x38

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OCA

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