3zqu
From Proteopedia
STRUCTURE OF A PROBABLE AROMATIC ACID DECARBOXYLASE
Structural highlights
FunctionUBIX_PSEAE Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.[HAMAP-Rule:MF_01984][1] Publication Abstract from PubMedThe ubiX gene (PA4019) of Pseudomonas aeruginosa has been annotated as encoding a putative 3-octaprenyl-4-hydroxybenzoate decarboxylase from the ubiquinone-biosynthesis pathway. Based on a transposon mutagenesis screen, this gene was also implicated as being essential for the survival of this organism. The crystal structure of recombinant UbiX determined to 1.5 A resolution showed that the protein belongs to the superfamily of homo-oligomeric flavine-containing cysteine decarboxylases. The enzyme assembles into a dodecamer with 23 point symmetry. The subunit displays a typical Rossmann fold and contains one FMN molecule bound at the interface between two subunits. Structure of PA4019, a putative aromatic acid decarboxylase from Pseudomonas aeruginosa.,Kopec J, Schnell R, Schneider G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1184-8., Epub 2011 Sep 24. PMID:22102023[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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