| Structural highlights
4ews is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| Method: | X-ray diffraction, Resolution 2.59Å |
Ligands: | , , , , , , , |
Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Disease
CETP_HUMAN Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:143470. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).[1] [2] [3]
Function
CETP_HUMAN Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.
References
- ↑ Inazu A, Brown ML, Hesler CB, Agellon LB, Koizumi J, Takata K, Maruhama Y, Mabuchi H, Tall AR. Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. N Engl J Med. 1990 Nov 1;323(18):1234-8. PMID:2215607 doi:http://dx.doi.org/10.1056/NEJM199011013231803
- ↑ Takahashi K, Jiang XC, Sakai N, Yamashita S, Hirano K, Bujo H, Yamazaki H, Kusunoki J, Miura T, Kussie P, et al.. A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins. J Clin Invest. 1993 Oct;92(4):2060-4. PMID:8408659 doi:http://dx.doi.org/10.1172/JCI116802
- ↑ Nagano M, Yamashita S, Hirano K, Ito M, Maruyama T, Ishihara M, Sagehashi Y, Oka T, Kujiraoka T, Hattori H, Nakajima N, Egashira T, Kondo M, Sakai N, Matsuzawa Y. Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay. J Lipid Res. 2002 Jul;43(7):1011-8. PMID:12091484
|