4nux
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proteopedia linkproteopedia linkStructure of receptor A
Structural highlights
DiseaseI17RA_HUMAN Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.[1] FunctionI17RA_HUMAN Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.[2] [3] See AlsoReferences
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Categories: Homo sapiens | Large Structures | Deng J | Han Y | Zhang B