4qnc

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Crystal structure of a SemiSWEET in an occluded state

Structural highlights

4qnc is a 2 chain structure with sequence from Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.388Å
Ligands:MYS, OLC
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SWEET_LEPBP The homodimer mediates transmembrane sugar transport down a concentration gradient. Transport is probably effected by rocking-type movements, where a cargo-binding cavity opens first on one and then on the other side of the membrane.[1]

References

  1. ↑ Xu Y, Tao Y, Cheung LS, Fan C, Chen LQ, Xu S, Perry K, Frommer WB, Feng L. Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature. 2014 Sep 3. doi: 10.1038/nature13670. PMID:25186729 doi:http://dx.doi.org/10.1038/nature13670

Contents


PDB ID 4qnc

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OCA

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