4qpj

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2.7 Angstrom Structure of a Phosphotransferase in Complex with a Receiver Domain

Structural highlights

4qpj is a 4 chain structure with sequence from Brucella abortus 2308. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.742Å
Ligands:CA, CL, GOL, MG, NA
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CHPT_BRUA2 Component of a regulatory phosphorelay system that controls B.abortus cell growth, division, and intracellular survival inside mammalian host cells. This signaling pathway is composed of CckA, ChpT, CtrA and CpdR. ChpT efficiently and specifically shuttles phosphoryl groups from the CckA kinase to the receiver domains of both CtrA and CpdR. Does not bind ATP. Overexpression of chpT results in a defect in cell morphology, DNA content, and intracellular survival in human macrophages.[1]

See Also

References

  1. ↑ Willett JW, Herrou J, Briegel A, Rotskoff G, Crosson S. Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen. Proc Natl Acad Sci U S A. 2015 Jun 29. pii: 201503118. PMID:26124143 doi:http://dx.doi.org/10.1073/pnas.1503118112

Contents


PDB ID 4qpj

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