Structural highlights
Function
PGL1_CAERE Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate (PubMed:26787882). Essential role in male and female postembryonic germline development; maternally provided protein maintains a population of proliferating germ cells and zygotic expression is required for correct oogenesis (By similarity). Together with the P-granule component pgl-3, is involved in the formation of P-granules (By similarity). Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules (By similarity). In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis during normal oogenesis and development of the two gonadal arms (By similarity). This may in part be through regulating the localization of sir-2.1 which is involved in germ cell apoptosis (By similarity). May protect somatic cells from excessive apoptosis during normal development (By similarity).[UniProtKB:Q9TZQ3][1]
References
- ↑ Aoki ST, Kershner AM, Bingman CA, Wickens M, Kimble J. PGL germ granule assembly protein is a base-specific, single-stranded RNase. Proc Natl Acad Sci U S A. 2016 Jan 19. pii: 201524400. PMID:26787882 doi:http://dx.doi.org/10.1073/pnas.1524400113
