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Publication Abstract from PubMed

The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au(NHC)+ fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl- ligand, but retaining NHC fragment.

First Crystal Structure for a Gold Carbene-Protein Adduct.,Ferraro G, Gabbiani C, Merlino A Bioconjug Chem. 2016 Jul 6. PMID:27364343^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.