Structural highlights
6hwl is a 2 chain structure with sequence from Streptacidiphilus jiangxiensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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Method: | X-ray diffraction, Resolution 2.148Å |
Ligands: | , , , , , , |
Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
GLCNK_STRJI Catalyzes the ATP-dependent phosphorylation of D-glucosamine (GlcN) to D-glucosamine 6-phosphate. May be involved in the phosphorylation of acquired extracellular GlcN derived from the hydrolysis of chitosan, i.e., in the incorporation of exogenous GlcN into the bacterial GlcNAc metabolism. To a lesser extent, is also active on glucose, but is unable to phosphorylate maltose, 18 other sugars and several aminoglycoside antibiotics.[1]
References
- ↑ Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB. Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity. MBio. 2019 May 14;10(3). pii: mBio.00239-19. doi: 10.1128/mBio.00239-19. PMID:31088917 doi:http://dx.doi.org/10.1128/mBio.00239-19