Structural highlights
Function
Q8A3I4_BACTN
Publication Abstract from PubMed
The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, alpha-L-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel alpha-L-fucosidase inhibitors, with X-ray crystallographic analysis using an alpha-L-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class.
Synthetic and crystallographic insight into exploiting sp2-hybridization in the development of alpha-L-fucosidase inhibitors.,Coyle T, Wu L, Debowski A, Davies G, Stubbs KA Chembiochem. 2019 Jan 21. doi: 10.1002/cbic.201800710. PMID:30663832[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Coyle T, Wu L, Debowski A, Davies G, Stubbs KA. Synthetic and crystallographic insight into exploiting sp2-hybridization in the development of alpha-L-fucosidase inhibitors. Chembiochem. 2019 Jan 21. doi: 10.1002/cbic.201800710. PMID:30663832 doi:http://dx.doi.org/10.1002/cbic.201800710
