7bw0

Structural highlights

Function

C562_ECOLX Electron-transport protein of unknown function.GPBAR_HUMAN Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.^{[1] [2]}

See Also

• Transducin 3D structures

References

1. ↑ Maruyama T, Miyamoto Y, Nakamura T, Tamai Y, Okada H, Sugiyama E, Nakamura T, Itadani H, Tanaka K. Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun. 2002 Nov 15;298(5):714-9. PMID:12419312 doi:10.1016/s0006-291x(02)02550-0
2. ↑ Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M. A G protein-coupled receptor responsive to bile acids. J Biol Chem. 2003 Mar 14;278(11):9435-40. PMID:12524422 doi:10.1074/jbc.M209706200