Enzymes: enzyme-substrate complex
From Proteopedia
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- Enzyme: Fructose biphosphate aldolase
- Substrate: fructose-1,6-biphosphate
- Products: glyceraldehyde-3-phosphate and dihydroxiacetone-phosphate.
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- This ribbon model shows secondary structures in Fructose biphosphate aldolase molecule.
- This wireframe model shows the polypeptide chain skeleton and amino acids R groups.
- The polypeptide chain of this enzyme consist of 363 amino acid residues.
- Now, we are going to soften colors to highligth the enzyme active site
- Active site is surrounded by 9 amino acid residues
- Substrate molecule, i.e., fructose-1,6-biphosphate. fits into active site.
- In this spacefill model, fit between active site and substrate is best seen.
- Zoom out to see a enzyme-substrate complex whole view.
- All models we have analyzed show a single subunit of fructose biphosphate aldolase. Really, this enzyme is a oligomeric protein composed of four subunits that perform a tetramer.
References
This page is based on the Proteopedia file 4ald.