Enzymes: enzyme-substrate complex

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Fructosa-bifosfato aldolasa (PDB 4ald)

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  • Enzyme: Fructose biphosphate aldolase
  • Substrate: fructose-1,6-biphosphate
  • Products: glyceraldehyde-3-phosphate and dihydroxiacetone-phosphate.
This ribbon model shows secondary structures in Fructose biphosphate aldolase molecule.
This wireframe model shows the polypeptide chain skeleton and amino acids R groups.
The polypeptide chain of this enzyme consist of 363 amino acid residues.
Now, we are going to soften colors to highligth the enzyme active site
Active site is surrounded by 9 amino acid residues
Substrate molecule, i.e., fructose-1,6-biphosphate. fits into active site.
In this spacefill model, fit between active site and substrate is best seen.
Zoom out to see a enzyme-substrate complex whole view.


All models we have analyzed show a single subunit of fructose biphosphate aldolase. Really, this enzyme is a oligomeric protein composed of four subunits that perform a tetramer.

References

This page is based on the Proteopedia file 4ald.

Proteopedia Page Contributors and Editors (what is this?)

Alejandro Porto

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