Hormone

From Proteopedia

proteopedia linkproteopedia link

In the field of modern endocrinology, a hormone is any substance, generated either externally or internally, that operates via a receptor at the cellular level, which conveys to to the cell a message to stop, start, or modulate a cellular process.

Guide to Proteopedia Pages Concerning Hormones and their Receptors

Articles in Proteopedia concerning Hormone include:

To view automatically seeded indices concerning Hormone, see:

• Hormone
• Hormone Receptor
• Steroid receptor
• Steroid hormone receptor

Additional 3D Structures of Hormones and Hormone Receptors and Related Molecules

Adrenaline

Beta-2 Adrenergic Receptor
The human β2 adrenergic receptor bound to a hormone analog and G-protein (3sn6) is featured in an image on the right, and additional structures are on the Adrenergic receptor page.

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image An activated G protein-coupled receptor (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) (3sn6), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green.

Angiotensinogen

Serpin

Chorionic Gonadotropin

1hrp, 1hcn - hCG – human
1hd4 - α-subunit of hCG
1e9j, 1dz7 - α-subunit of hCG - NMR
1qfw - hCG + antibody

Estrogen receptor

Estrogen receptor

Estrogen-related Receptor

Estrogen-related receptor

Androgen Receptor

Nuclear Androgen Receptor

Follicle-Stimulating Hormone

Follicle-stimulating hormone

PACAP/glucagon family of peptide hormones

3n94 - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure 2jod and vice versa
2jod - Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular

Glucocorticoid

Glucocorticoid receptor

Glucose-dependent Insulinotropic Polypeptide

Glucose-dependent Insulinotropic Polypeptide Receptor

Growth Hormone

Human growth hormone is featured here.

Insulin

Insulin

Progesterone

1a28 - hProgR steroid-binding domain + progesterone

See Also

• Cancer
• Membrane proteins
• G protein-coupled receptors
• Nobel Prizes for 3D Molecular Structure
• Highest impact structures of all time
• Hormones and their receptors

External Resources

• Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors
• GRIS: Glycoprotein-hormone Receptors Information System
• The GPCR-SSFE Database: A Homology Model Resource for G-Protein Coupled Receptors
• The feature on Growth Hormone by Shuchismita Dutta and David S. Goodsell for the April 2004 RCSB PDB Molecule of the Month.
• NeuroPedia, a neuropeptide database and spectral library