Hormone

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In the field of modern endocrinology, a hormone is any substance, generated either externally or internally, that operates via a receptor at the cellular level, which conveys to to the cell a message to stop, start, or modulate a cellular process.

Guide to Proteopedia Pages Concerning Hormones and their Receptors

Articles in Proteopedia concerning Hormone include:


To view automatically seeded indices concerning Hormone, see:


Additional 3D Structures of Hormones and Hormone Receptors and Related Molecules

Adrenaline

Beta-2 Adrenergic Receptor
The human β2 adrenergic receptor bound to a hormone analog and G-protein (3sn6) is featured in an image on the right, and additional structures are on the Adrenergic receptor page.

 

An activated G protein-coupled receptor (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) (3sn6), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green.



Angiotensinogen

2wxw, 2wxx, 2wxy, 2wxz, 2wy0, 2wy1, 2x0b - Angiotensinogen – human, rat, mouse

Chorionic Gonadotropin

1hrp - Chorionic Gonadotropin – human
1hcn - Chorionic Gonadotropin – human
1hd4 - Alpha-subunit of Chorionic Gonadotropin – human

Estrogen-related Receptor

Estrogen-related receptor – human and others, see Estrogen-related receptor structures

Androgen Receptor

Nuclear Androgen Receptor

Farnesoid X Receptor

3olf, 3omk, 3omm, 3oof, 3ook, 3okh, 3oki - Farnesoid X Receptor – human

Follicle-Stimulating Hormone

1fl7 - Follicle-Stimulating Hormone – human
1xwd - Human Follicle Stimulating Hormone complexed with the Leucine-repeat region of the binding domain of its receptor– human

FSH binding to the leucine-rich domain of Follicle Stimulating Hormone Receptor (1fl7 morphing to 1xwd, resolution 2.92Å)


Human Follicle-Stimulating Hormone Complexed with its Receptor is featured here.
4ay9 - Human Follicle Stimulating Hormone complexed with the entire ectodomain of its receptor – human

PACAP/glucagon family of peptide hormones

3n94 - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure 2jod and vice versa
2jod - Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular

Glucocorticoid

3mne, 3mno, 3mnp - Glucocorticoid Receptor Ligand-binding Domain – human

Glucose-dependent Insulinotropic Polypeptide

Glucose-dependent Insulinotropic Polypeptide Receptor

Growth Hormone

Human growth hormone is featured here.
3hhr - Growth Hormone complexed with the extracellular portion of its receptor - human
1hwh,1a22 - Growth Hormone Mutant G120R complexed with the extracellular portion of its receptor - human
1bp3 - Growth Hormone complexed with the prolactin receptor - human
3mjg, 3mjk - Platelet-derived Growth Factor/Propeptide Complex and a Platelet-Derived Growth Factor/Receptor Complex – human
Vascular Endothelial Growth Factor – human and others, see Vascular Endothelial Growth Factor Structures
Vascular Endothelial Growth Factor Receptor – human, see Vascular Endothelial Growth Factor Receptor Structures
2xdg - Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor – human
1axi – HGH (mutant) + HGH receptor (mutant)

Insulin

3ir0 , 1mso , 1trz , 2qiu , 2r34, 2r35 , 2r36, 3ilg, 2kjj , 2kju - Insulin – human
3nw5, 3nw6, 3nw7 - insulin-like growth factor 1 receptor – human
3loh, 2dtg - insulin receptor ectodomain – human
Glucose-dependent Insulinotropic Polypeptide Receptor

Progesterone

3hq5,3g8n, 3g8o, 3hq5 - Progesterone – human

Thyroid-Stimulating hormone

3g04 - TSH receptor in complex with a thyroid-stimulating autoantibody – human
2xwt - TSH receptor in complex with a thyroid-inactivating autoantibody – human

Thyroid hormone

2nll - DNA-Binding domain in complex with an inverted repeat class of thyroid response element– rat
1xzx

Thyroxine

2xn3, 2xn5, 2xn6, 2xn7 - Thyroxine-binding Globulin – human


domain of the human splice variant hPAC1-RS determined by NMR - human



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See Also


External Resources

Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Tomas Klumpler

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