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Molecular Playground/Insulin

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>One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst in the Roberts Research Group and on display at the Molecular Playground.

Human insulin chain A (grey) and chain B (green), 3i40

For additional details see Insulin Structure & Function.

Contents

3D structures of insulin

Updated on 18-March-2014

3i3z, 3i40, 3e7y, 3e7z, 2qiu, 2c8q, 2c8r, 1q4v, 1os3, 1os4, 1mso, 1guj, 1g7a, 1g7b, 1xda, 1trz, 3zqr, 3zs2, 3zu1, 2lgb, 3v19, 3v1g, 4ajx, 4ajz, 4ak0, 4akj, 4eww, 4ewx, 4ewz, 4ex0, 4ex1, 4exx, 4ey1, 4ey9, 4eyd, 4eyn, 4eyp, 4f0n, 4f0o, 4f1a, 4f1b, 4f1c, 4f1d, 4f1f, 4f1g, 4f4t, 4f4v, 4f51, 4f8f, 4fg3, 4fka, 4gbc, 4gbi, 4gbk, 4gbl, 4gbn, 2m1d, 4iyd, 4iyf - hIns A chain + B chain – human
1fu2, 1fub - hIns A chain + B chain – powder diffraction
2kxk, 3bxq, 1b9e, 3rov, 3u4n, 4iuz, 2m1e, 2m2m, 2m2n, 2m2o, 2m2p – hIns A chain + B chain (mutant)
1zeh, 3zi3 - hIns A chain (mutant) + B chain (mutant)
3ir0, 3inc, 3ilg, 3kq6, 3exx, 2r34, 2r35, 2r36, 3tt8 - hIns A chain + B chain + non-Zn metal ion
3fq9, 1xw7, 1rwe, 1jca, 1j73, 4efx - hIns A chain (mutant) + B chain
1w8p - hIns A chain + B chain (mutant)
2w44 - hIns A chain residues 82-98 + B chain residues 25-53
2wru, 2wrv, 2wrw, 2wrx, 2ws0, 2ws1, 2ws4, 2ws6, 2ws7, 1qj0 - hIns A chain + B chain residues 25-54 (mutant)
3jsd, 2vjz, 2vk0, 1uz9, 3p33, 3w7y, 3w7z, 3w80 - hIns A chain residues 90-110 + B chain residues 25-54
3p2x - hIns A chain residues 90-110 + B chain residues 25-54 (mutant)
3gky, 2g4m, 1zni, 1znj, 1wav, 1iza, 1izb, 9ins, 4ins, 3ins, 3t2a, 4a7e - pIns A chain + B chain – pig
2zpp, 2efa - pIns A chain + B chain – Neutron
2zp6, 1aph, 1bph, 1cph, 1dph, 4e7t, 4e7u, 4e7v, 4idw, 4bs3, 4i5y, 4i5z, 4ihn, 4m4f, 4m4h, 4m4i, 4m4j, 4m4l, 4m4m - bIns A chain + B chain – bovine
2a3g, 2bn1, 2bn3 - bIns A chain residues 85-105 + B chain residues 25-54
3rto, 3fhp - pIns A chain residues 88-108 + B chain residues 25-54
1m5a - pIns A chain + B chain + non-Zn metal ion
6ins – pIns single chain

Insulin structures using NMR

1sf1, 2aiy, 3aiy, 4aiy, 5aiy, 1ai0, 1aiy, 1xgl, 1hiq, 1hit - hIns A chain + B chain – NMR
2hiu – apo-hIns A chain + B chain – NMR
2kqq, 1t1k, 1t1p, 1t1q - hIns A chain (mutant) + B chain – NMR
2jmn, 2h67, 2hh4, 2hho, 1jco, 1a7f - hIns A chain + B chain (mutant) – NMR
2jum, 2juu, 2juv, 1kmf, 1k3m, 1bzv, 1vkt, 1hui, 1mhi, 1mhj, 1hls - hIns A chain (mutant) + B chain (mutant) – NMR
2l1y, 2l1z - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 - NMR
2kjj, 2kju, 2k91, 2k9r, 2rn5 - hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR
1lkq - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 (mutant) – NMR
2jv1 – apo-hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR
2jzq - hIns A chain – NMR
1ho0 - hIns B chain (mutant) – NMR
2lwz – hIns single chain - NMR

Insulin complexes

3brr - hIns A chain + B chain + sulfatide
1ben - hIns A chain + B chain + hydroxybenzamide
1tyl, 1tym - hIns A chain + B chain + hydroxyacetanilide
2oly, 2om0, 2omh, 2omi - hIns A chain + B chain + urea + resorcinol
2omg - hIns A chain + B chain + urea + cresol
2olz, 2om1 - hIns A chain + B chain + thiocyanate
1jk8 - hIns B chain peptide + HLA
1zeg, 1lph - hIns A chain (mutant) + B chain (mutant) + phenol
1qiy - hIns A chain + B chain residues 25-54 (mutant) + phenol
1qiz - hIns A chain + B chain residues 25-54 (mutant) + resorcinol
1ev3, 1ev6 - hIns A chain residues 87-107 + B chain residues 25-54+ cresol
1evr - hIns A chain residues 87-107 + B chain residues 25-54+ resorcinol
3q6e - hIns A chain residues 90-110 + B chain residues 25-54+ synthetic receptor
2g54, 2g56 - hIns B chain residues 25-54 + insulin-degrading enzyme
2wby, 2wc0 - hIns A chain residues 90-109 + B chain residues 25-54 + insulin-degrading enzyme (mutant)
3w11 - hIns A chain + B chain + insulin-degrading enzyme + antibody
1b17, 1b18, 1b19, 1b2a, 1b2b, 1b2c, 1b2d, 1b2e, 1b2f, 1b2g - pIns A chain + B chain + sulfate
1mpj - pIns A chain + B chain + phenol
2tci - pIns A chain + B chain + thiocyanate
3mth - pIns A chain + B chain + methylparaben
1zei - pIns A chain (mutant) + cresol
7ins - pIns A chain + B chain + clupeine + cresol
3w14 - bIns A chain + B chain + insulin-degrading enzyme + antibody

Proinsulin

2kqp – hPIns A chain – NMR
1t0c - hPIns A chain residues 57-87 – NMR
1iog, 1ioh, 1sjt - hPIns A chain (mutant) + B chain (mutant) – NMR
1efe – mini-hPIns
1sju - mini-hPIns (mutant)

Despeptide insulin

2ceu – DPI – yeast
1sdb - pDPI A chain + B chain
1pid - bDPI A chain + B chain
1his - hDPI A chain + B chain]] - NMR
1htv – hDTRI A chain + B chain
1dei – pDHPI A chain (mutant) + B chain (mutant)
2ins – bD-Phe Ins chain A + chain B

Leginsulin

1ju8 – Lins A chain residues 1-37 – legume - NMR




Additional Resources

For additional information, see: Diabetes & Hypoglycemia

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, David Canner, Whitney Stoppel, Alexander Berchansky, Yael Shwartz, Lynmarie K Thompson

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