Triose Phosphate Isomerase

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This page, as it appeared on June 30, 2011, was featured in this article in the Journal of Biochemistry and Molecular Biology Education.

TPI (yeast) at 2.5 Å resolution (2ypi) dimer. The two identical chains are in grey and green. Ligand is the inhibitor 2-phosphoglycolic acid (PGA).

Contents

3D Structures of triose phosphate isomerase

Updated on 12-November-2017

Additional Resources

Acknowledgements

The authors of this proteopedia page would like to acknowledge and thank the authors of Triosephosphate Isomerase: Paula Grabowski, Jacqueline Townsend, Kara Pryke, and Regina D. Kettering. Some content from that article was incorporated into the present article.

References

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  2. Harris TK, Abeygunawardana C, Mildvan AS. NMR studies of the role of hydrogen bonding in the mechanism of triosephosphate isomerase. Biochemistry. 1997 Dec 2;36(48):14661-75. PMID:9398185 doi:10.1021/bi972039v
  3. Saadat D, Harrison DH. The crystal structure of methylglyoxal synthase from Escherichia coli. Structure. 1999 Mar 15;7(3):309-17. PMID:10368300
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  5. Rozovsky S, McDermott AE. Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2080-5. Epub 2007 Feb 7. PMID:17287353 doi:http://dx.doi.org/0608876104
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  13. Fonvielle M, Mariano S, Therisod M. New inhibitors of rabbit muscle triose-phosphate isomerase. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2906-9. PMID:15911278 doi:10.1016/j.bmcl.2005.03.061
  14. Kursula I, Wierenga RK. Crystal structure of triosephosphate isomerase complexed with 2-phosphoglycolate at 0.83-A resolution. J Biol Chem. 2003 Mar 14;278(11):9544-51. Epub 2003 Jan 9. PMID:12522213 doi:http://dx.doi.org/10.1074/jbc.M211389200
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  17. http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv
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  24. Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M, Miscione GP, Villa-Freixa J, Suzuki T, Fernandez-Busquets X, Valverde MA, de Strooper B, Munoz FJ. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain. 2009 May;132(Pt 5):1335-45. Epub 2009 Feb 27. PMID:19251756 doi:10.1093/brain/awp023
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  26. The conservation pattern shown was calculated by ConSurfDB and might obscure some conservation due to inclusion of proteins of different functions. However in the case of 2ypi, all sequences used in the multiple sequence alignment were TPI sequences. A manual run at the ConSurf Server, using 500 TPI sequences, gave a nearly identical result. Both runs gave an average pairwise distance close to 1.0. Hence, the conservation pattern shown is correct for TPI.

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