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As life is more than 2D, Proteopedia helps to bridge the gap between 3D structure & function of biomacromolecules

Proteopedia presents this information in a user-friendly way as a collaborative & free 3D-encyclopedia of proteins & other biomolecules.


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Green Fluorescent Protein

by Eran Hodis
Green fluorescent protein (GFP) is a bioluminescent polypeptide isolated from the jellyfish Aequorea victoria. GFP converts the blue chemiluminescence of aequorin into green fluorescent light. In the laboratory, GFP can be incorporated into a variety of biological systems in order to function as a marker protein. Since its discovery in 1962, GFP has become a significant contributor to the research of monitoring gene expression, localization, mobility, traffic, or interactions between various membrane and cytoplasmic proteins.

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Structure of Anticancer Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3ß

G Atilla-Gocumen, L Di Costanzo, E Meggers. J Biol Inorg Chem. 2010 doi: 10.1007/s00775-010-0699-x
A crystal structure of an organometallic half-sandwich ruthenium complex bound to glycogen synthase kinase 3ß (GSK-3ß) reveals that the inhibitor binds to the ATP binding site via an induced fit mechanism utilizing several hydrogen bonds and hydrophobic interactions. Importantly, the metal is not involved in any direct interaction with the protein kinase but fulfills a purely structural role.

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Eastern Equine Encephalitis virus
Although only a few people in the USA get Eastern Equine Encephalitis every year, the fatality rate is 30%, and many survivors have ongoing neurological problems. The virus is transmitted by mosquitoes from animals, especially birds, to humans. This RNA virus has a complicated capsid (a slab of which is shown) composed of protein shells with an enclosed lipid bilayer. The structures of virus capsids can be explored using free FirstGlance in Jmol.

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