2xwc

Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution

spinqualitylabelsall models 2xwc, resolution 1.82Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2xwc is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2xip. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.82Å Ligands: GOL, TAM, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function P73_HUMAN Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. See Also P73

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