3rrc

Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein

spinqualitylabelsall models 3rrc, resolution 1.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3rrc is a 2 chain structure with sequence from Plasmodium vivax Sal-1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.95Å Ligands: EDO, PO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PVDR_PLAVS Binds to the human erythrocytes Duffy blood group determinant. Publication Abstract from PubMed Plasmodium vivax and Plasmodium knowlesi invasion depends on the parasite Duffy-binding protein DBL domain (RII-PvDBP or RII-PkDBP) engaging the Duffy antigen receptor for chemokines (DARC) on red blood cells. Inhibition of this key interaction provides an excellent opportunity for parasite control. There are competing models for whether Plasmodium ligands engage receptors as monomers or dimers, a question whose resolution has profound implications for parasite biology and control. We report crystallographic, solution and functional studies of RII-PvDBP showing that dimerization is required for and driven by receptor engagement. This work provides a unifying framework for prior studies and accounts for the action of naturally acquired blocking antibodies and the mechanism of immune evasion. We show that dimerization is conserved in DBL-domain receptor engagement and propose that receptor-mediated ligand dimerization drives receptor affinity and specificity. Because dimerization is prevalent in signaling, our studies raise the possibility that induced dimerization may activate pathways for invasion. Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC.,Batchelor JD, Zahm JA, Tolia NH Nat Struct Mol Biol. 2011 Jul 10;18(8):908-14. doi: 10.1038/nsmb.2088. PMID:21743458 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Erythrocyte binding antigen

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