3s68

Rat COMT in complex with SAM and Tolcapone at 1.85A, P3221, Rfree=22.0

spinqualitylabelsall models 3s68, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3s68 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.85Å Ligands: CL, MG, SAM, SO4, TCW Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function COMT_RAT Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. See Also Catechol O-methyltransferase 3D structures

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