3u54

Crystal structure (Type-1) of SAICAR synthetase from Pyrococcus horikoshii OT3

spinqualitylabelsall models 3u54, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3u54 is a 2 chain structure with sequence from Pyrococcus horikoshii OT3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.35Å Ligands: ACT, BU1, CD, MSE, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PUR7_PYRHO Publication Abstract from PubMed The first native crystal structure of Phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase) from a hyperthermophilic organism Pyrococcus horikoshii OT3 was determined in two space groups H3 (Type-1: Resolution 2.35A) and in C222(1) (Type-2: Resolution 1.9A). Both are dimeric but Type-1 structure exhibited hexameric arrangement due to the presence of cadmium ions. A comparison has been made on the sequence and structures of all SAICAR synthetases to better understand the differences between mesophilic, thermophilic and hyperthermophilic SAICAR synthetases. These SAICAR synthetases are reasonably similar in sequence and three-dimensional structure; however, differences were visible only in the subtler details of percentage composition of the sequences, salt bridge interactions and non-polar contact areas. Structure of SAICAR synthetase from Pyrococcus horikoshii OT3: insights into thermal stability.,Manjunath K, Kanaujia SP, Kanagaraj S, Jeyakanthan J, Sekar K Int J Biol Macromol. 2013 Feb;53:7-19. doi: 10.1016/j.ijbiomac.2012.10.028. Epub , 2012 Nov 5. PMID:23137517 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also SAICAR synthetase

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