4b8l

Aurora B kinase P353G mutant

spinqualitylabelsall models 4b8l, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4b8l is a 2 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Ligands: A0P Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function INCEA_XENLA Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with aurkb or aurkc. Seems to bind directly to microtubules. See Also Centromere protein 3D structure Serine/threonine protein kinase 3D structures

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