4b8x

Near atomic resolution crystal structure of Sco5413, a MarR family transcriptional regulator from Streptomyces coelicolor

spinqualitylabelsall models 4b8x, resolution 1.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4b8x is a 2 chain structure with sequence from Streptomyces coelicolor. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.25Å Ligands: CL, CME Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9L2A7_STRCO Publication Abstract from PubMed The crystal structure of Sco5413 from Streptomyces coelicolor A3(2) has been determined at 1.25 A resolution, the highest resolution reported for a MarR family transcriptional regulator. Putative orthologs are encoded by the majority of sequenced actinomycete genomes, and may play roles in regulating growth and antibiotic production, but they have yet to be assigned a precise function. Sco5413 forms a homodimer and, through comparisons with other MarR family protein structures, we postulate that it adopts a conformation compatible with DNA binding, and that a channel at the dimer interface, lined by well-conserved residues, is the binding site of an unidentified effector ligand. Proteins 2012. (c) 2012 Wiley Periodicals, Inc. High resolution crystal structure of Sco5413, a widespread actinomycete MarR family transcriptional regulator of unknown function.,Holley TA, Stevenson CE, Bibb MJ, Lawson DM Proteins. 2012 Oct 8. doi: 10.1002/prot.24197. PMID:23042442 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Transcriptional activator 3D structures

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