4nn5

Cytokine receptor complex - Crystal form 1A

spinqualitylabelsall models 4nn5, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4nn5 is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.898Å Ligands: ACT, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function IL7RA_MOUSE Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). Publication Abstract from PubMed Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR) and the shared interleukin 7 receptor alpha-chain (IL-7Ralpha) to evoke membrane-proximal receptor-receptor contacts poised for intracellular signaling. Binding of TSLP to TSLPR is a mechanistic prerequisite for recruitment of IL-7Ralpha to the high-affinity ternary complex, which we propose is coupled to a structural switch in TSLP at the crossroads of the cytokine-receptor interfaces. Functional interrogation of TSLP-receptor interfaces points to putative interaction hotspots that could be exploited for antagonist design. Finally, we derive the structural rationale for the functional duality of IL-7Ralpha and establish a consensus for the geometry of ternary complexes mediated by interleukin 2 (IL-2)-family cytokines. Structural basis of the proinflammatory signaling complex mediated by TSLP.,Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, Peelman F, Savvides SN Nat Struct Mol Biol. 2014 Mar 16. doi: 10.1038/nsmb.2794. PMID:24632570 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Interleukin receptor 3D structures

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