4yd0

Influenza polymerase basic protein 2 (PB2) bound to an azaindole-tetrazole inhibitor

spinqualitylabelsall models 4yd0, resolution 2.62Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4yd0 is a 1 chain structure with sequence from Influenza A virus (A/Beijing/39/1975(H3N2)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.62Å Ligands: 4EW Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PB2_I75A0 Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428] See Also RNA polymerase 3D structures

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