4z2d

Quinolone(Levofloxacin)-DNA cleavage complex of gyrase from S. pneumoniae

spinqualitylabelsall models 4z2d, resolution 3.38Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4z2d is a 8 chain structure with sequence from Escherichia coli and Streptococcus pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.38Å Ligands: LFX, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GYRA_STRR6 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] See Also Gyrase 3D Structures

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