Structural highlights
Function
TFC3_YEAST TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding.[1] [2] [3]
See Also
References
- ↑ Lefebvre O, Carles C, Conesa C, Swanson RN, Bouet F, Riva M, Sentenac A. TFC3: gene encoding the B-block binding subunit of the yeast transcription factor IIIC. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10512-6. PMID:1279682
- ↑ Gabrielsen OS, Marzouki N, Ruet A, Sentenac A, Fromageot P. Two polypeptide chains in yeast transcription factor tau interact with DNA. J Biol Chem. 1989 May 5;264(13):7505-11. PMID:2651441
- ↑ Arrebola R, Manaud N, Rozenfeld S, Marsolier MC, Lefebvre O, Carles C, Thuriaux P, Conesa C, Sentenac A. Tau91, an essential subunit of yeast transcription factor IIIC, cooperates with tau138 in DNA binding. Mol Cell Biol. 1998 Jan;18(1):1-9. PMID:9418847
