6aw5
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1.90A resolution structure of catechol O-methyltransferase (COMT) L136M (hexagonal form) from Nannospalax galili
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Structural highlights
FunctionA0A452CSQ2_NANGA Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.[ARBA:ARBA00003256] See AlsoContents | ||||||||||||||||||||
This page was last modified 14:26, 4 October 2023.