6c0w

Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing CENP-A

Loading... Status: waiting for Mol* initialization Structural highlights 6c0w is a 11 chain structure with sequence from Escherichia coli str. 'clone D i2' and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CENPA_HUMAN Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro). See Also Centromere protein 3D structure

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