6cm1

MT1-MMP HPX Domain with Blade 2 Loop Bound to Nanodiscs

spinqualitylabelsall models 6cm1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6cm1 is a 3 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Ligands: CL, NA, PX4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MMP14_HUMAN Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. See Also Matrix metalloproteinase 3D structures

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