6fq2

Structure of minimal sequence for left -handed G-quadruplex formation

spinqualitylabelsall models 6fq2, resolution 2.31Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6fq2 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: K Related: 4u5m Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Recently, we observed the first example of a left-handed G-quadruplex structure formed by natural DNA, named Z-G4. We analysed the Z-G4 structure and inspected its primary 28-nt sequence in order to identify motifs that convey the unique left-handed twist. Using CD, NMR spectroscopy and X-ray crystallography, we revealed a minimal sequence motif of 12 nt GTGGTGGTGGTG for the left-handed DNA G-quadruplex formation, which is found to be highly abundant in the human genome. A systematic analysis of thymine loop mutations revealed a moderate sequence tolerance, which would further broaden the space of sequences prone to left-handed G-quadruplex formation. A minimal sequence for left-handed G-quadruplex formation.,Phan AT Angew Chem Int Ed Engl. 2018 Nov 27. doi: 10.1002/anie.201812628. PMID:30481397 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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