6n1e

Crystal structure of X. citri phosphoglucomutase in complex with 1-methyl-glucose 6-phosphate

spinqualitylabelsall models 6n1e, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6n1e is a 1 chain structure with sequence from Xanthomonas citri. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.7Å Ligands: MG, QIF Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Glucokinase phosphorylated a series of C-1 fluorinated alpha-d-gluco-heptuloses. These phosphorylated products were discovered to be inhibitors of alpha-phosphomannomutase/phosphoglucomutase (alphaPMM/PGM) and beta-phosphoglucomutase (betaPGM). Inhibition potency with both mutases inversely correlated to the degree of fluorination. Structural analysis with alphaPMM demonstrated the inhibitor binding to the active site, with the phosphate in the phosphate binding site and the anomeric hydroxyl directed to the catalytic site. Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono-, Di-, and Trifluorinated d-Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition.,Zhu JS, Stiers KM, Winter SM, Garcia AD, Versini AF, Beamer LJ, Jakeman DL ACS Omega. 2019 Apr 30;4(4):7029-7037. doi: 10.1021/acsomega.9b00008. Epub 2019, Apr 18. PMID:31179410 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Phosphomannomutase

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