6n1p

Dihedral oligomeric complex of GyrA N-terminal fragment with DNA, solved by cryoEM in C2 symmetry

Loading... Status: waiting for Mol* initialization Structural highlights 6n1p is a 10 chain structure with sequence from Cloning vector pBR322 and Streptococcus pneumoniae G54. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 6.35Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GYRA_STRR6 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] See Also Gyrase 3D Structures

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