6rr7

Influenza A virus (A/NT/60/1968) polymerase Heterotrimer bound to 3'5' vRNA promoter and capped RNA primer

Loading... Status: waiting for Mol* initialization Structural highlights 6rr7 is a 6 chain structure with sequence from Influenza A virus (A/nt/60/1968(H3N2)) and Spodoptera frugiperda. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.01Å Ligands: M7G Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RDRP_I68A6 RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs. See Also RNA polymerase 3D structures

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