6v00

structure of human KCNQ1-KCNE3-CaM complex

Loading... Status: waiting for Mol* initialization Structural highlights 6v00 is a 12 chain structure with sequence from Anaplasma marginale and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.1Å Ligands: CA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease KCNE3_HUMAN Brugada syndrome;Hypokalemic periodic paralysis. Function X5DSL3_ANAMA KCNE3_HUMAN Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.[UniProtKB:Q9JJV7] See Also Calmodulin 3D structures Green Fluorescent Protein 3D structures Potassium channel 3D structures

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