Structural highlights
6w65 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.13Å |
| Ligands: | CIT, EDO, GOL, PEG, T9D |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
PAR16_HUMAN Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors.[1] [2]
See Also
References
- ↑ Jwa M, Chang P. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1alpha-mediated unfolded protein response. Nat Cell Biol. 2012 Nov;14(11):1223-30. doi: 10.1038/ncb2593. Epub 2012 Oct 28. PMID:23103912 doi:https://dx.doi.org/10.1038/ncb2593
- ↑ Di Paola S, Micaroni M, Di Tullio G, Buccione R, Di Girolamo M. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ss1. PLoS One. 2012;7(6):e37352. doi: 10.1371/journal.pone.0037352. Epub 2012 Jun 11. PMID:22701565 doi:https://dx.doi.org/10.1371/journal.pone.0037352
