6whb

MEKK1 TOG domain (548-867)

spinqualitylabelsall models 6whb, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6whb is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.9003205Å Ligands: ACT, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease M3K1_HUMAN 46,XY partial gonadal dysgenesis;46,XY complete gonadal dysgenesis. The disease is caused by mutations affecting the gene represented in this entry. Function M3K1_HUMAN Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). See Also Mitogen-activated protein kinase kinase 3D structures Mitogen-activated protein kinase kinase kinase

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