6zq6

Crystal structure of Chaetomium thermophilum Glycerol Kinase in complex with glycerol in P21212 space group

spinqualitylabelsall models 6zq6, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6zq6 is a 4 chain structure with sequence from Chaetomium thermophilum var. thermophilum DSM 1495. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.3Å Ligands: ACT, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G0SAG9_CHATD Publication Abstract from PubMed Glycerol is an organic compound that can be utilized as an alternative source of carbon by various organisms. One of the ways to assimilate glycerol by the cell is the phosphorylative catabolic pathway in which its activation is catalyzed by glycerol kinase (GK) and glycerol-3-phosphate (G3P) is formed. To date, several GK crystal structures from bacteria, archaea, and unicellular eukaryotic parasites have been solved. Herein, we present a series of crystal structures of GK from Chaetomium thermophilum (CtGK) in apo and glycerol-bound forms. In addition, we show the feasibility of an ADP-dependent glucokinase (ADPGK)-coupled enzymatic assay to measure the CtGK activity. New structures described in our work provide structural insights into the GK catalyzed reaction in the filamentous fungus and set the foundation for understanding the glycerol metabolism in eukaryotes. Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum.,Wilk P, Kuska K, Wator E, Malecki PH, Wos K, Tokarz P, Dubin G, Grudnik P Int J Mol Sci. 2020 Dec 16;21(24). pii: ijms21249570. doi: 10.3390/ijms21249570. PMID:33339113 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glycerol kinase

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