7wzs

Crystal structure of Chromobacterium violaceum effector CopC in complex with host calmodulin and caspase-7

spinqualitylabelsall models 7wzs, resolution 3.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7wzs is a 3 chain structure with sequence from Chromobacterium violaceum ATCC 12472 and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.6Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function COPC_CHRVO ADP-riboxanase effector that inhibits host cell pyroptosis (PubMed:34671164). Acts by mediating arginine ADP-riboxanation of host CASP4/CASP11, blocking CASP4/CASP11 autoprocessing (PubMed:34671164). This prevents CASP4 activation and ability to recognize and cleave GSDMD, thereby inhibiting LPS-induced pyroptosis (PubMed:34671164). ADP-riboxanation takes place in two steps: CopC first catalyzes ADP-ribosylation of target Arg, and then initiates a deamination to remove one N-omega group (By similarity).[UniProtKB:A0A0H2US87] See Also Calmodulin 3D structures Caspase 3D structures

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