Adrenergic receptor

Crystal Structure of β-2 Adrenergic Receptor, Beta-2 adrenergic receptor

spinqualitylabelsall models β-2 Adrenergic Receptor (grey) complex with antibody heavy chain (red) and light chain (aqua) (PDB code 2r4r). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function The adrenergic receptors are metabolic G protein-coupled receptors. They are the targets of catecholamines. The binding of an agonist to them causes a sympathetic response. The α-2 adrenergic receptor (A2AR) inhibits insulin or glucagons release. The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin. The β-2 adrenergic receptor (B2AR) triggers many relaxation reactions. See Beta-2 adrenergic receptor and Beta2 adrenergic receptor-Gs protein complex updated The β-3 adrenergic receptor (B3AR) is active in lipid metabolism. See also G protein-coupled receptor Beta2 adrenergic receptor-Gs protein complex The Madison West High School 2008 SMART Team's Page on the β-2 adrenergic receptor UMass Chem 423 Student Projects 2011-1 Neurodevelopmental Disorders Transmembrane (cell surface) receptors. Click here to see transition from active to inactive conformation of alpha adrenergic receptor (morph was taken from Gallery of Morphs of the Yale Morph Server).   β2 adrenergic receptor binding a hormone analog and complexed to a heterotrimeric G protein (3sn6)   spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load= size='550' frame='false' scene='Template:GPCR3sn6/3sn6memrane/15' An activated G protein-coupled receptor (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) (3sn6), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green. Initial scene Relevance Alprenolol and Propranolol are B2AR antagonists used in treatment of angina pectoris. Timolol ia a B2AR antagonist used in treatment of glaucoma. Carvedilol is A2AR and B2AR antagonist used in treatment of high blood pressure. Salbutamol (Ventolin) and Salmeterol are B2AR agonists used for muscle relaxation in asthma attacks. 3D Structures of Adrenergic receptor Adrenergic receptor 3D structures This is the first structure of an activated GPCR in a complex with its G protein. Nobel Prize Related to the Structures Robert J. Lefkowitz and Brian K. Kobilka share the 2012 Nobel Prize in Chemistry for work on GPCRs that includes solving the first structures of a ligand-activated GPCR (2r4r, 2r4s, & 2rh1 in 2007) and the first activated GPCR in complex with its G protein (3sn6 in 2011). A detailed description of the laureates' body of work on this class of receptors with images is here.

See Also

• Beta2 adrenergic receptor-Gs protein complex updated
• G protein-coupled receptor
• Beta2 adrenergic receptor-Gs protein complex
• Highest impact structures of all time
• UMass Chem 423 Student Projects 2011-1
• Neurodevelopmental Disorders
• Transmembrane (cell surface) receptors
• 3sn6
• 3sn6
• Alprenolol
• Propranolol
• Timolol

External Resources

• Robert J. Lefkowitz and Brian K. Kobilka share the 2012 Nobel Prize in Chemistry for work on GPCRs that includes solving the first structures of a ligand-activated GPCR (2007) and the first activated GPCR in complex with its G protein (2011). A detailed description of the laureates' body of work on this class of receptors with images is here.
• The April 2008 RCSB PDB Molecule of the Month feature on Adrenergic Receptors by David S. Goodsell is 10.2210/rcsb_pdb/mom_2008_4.

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Alexander Berchansky, Wayne Decatur, Karsten Theis, Michal Harel