D-alanine-D-alanine ligase

spinqualitylabelsall models Structure of D-alanine-D-alanine ligase dimer complex with ADP (stick model), sulfate and Mg+2 ion (green) (PDB entry 2i8c) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function D-alanine-D-alanine ligase (DDL) catalyzes the conversion of 2 alanine molecules and ATP to D-alanine-D-alanine and ADP. DDL is part of the bacterial peptidoglycan synthesis pathway and the alanine metabolism. Relevance DDL acts in bacterial cell wall synthesis and its inhibition is a target of novel antibiotics search. Structural highlights DDL structure contains 3 α/β domains (Alpha Helices, Beta Strands , Loops , Turns). The ADP-binding site is found between domains 1 and 2. 3D structures of D-alanine-D-alanine ligase D-alanine-D-alanine ligase 3D structures

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