Epidermal growth factor receptor 3D structures

3D Structures of Epidermal Growth Factor Receptor

Updated on 01-June-2025

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• EGFR extracellular domain (residues 25-642)
  • 1yy9, 4kro, 4krp, 4uv7, 4uip, 5xwd, 3n85, 6aru – hERBB1+antibody - human
    
  • 5lv6 – hERBB1
    
  • 1m6b – hERBB3
    
  • 1mox - hEGFR +TGF alpha
    
  • 7sz5, 7sz7 - hEGFR +hTGF alpha – Cryo EM
    
  • 1ivo, 3njp - hEGFR +hEGF 1-53
    
  • 1nql - hEGFR +hEGF 971-1023
    
  • 7syd, 7sye, 7sz0, 7sz1, 8hgs - hEGFR +hEGF 971-1023 – Cryo EM
    
  • 7om4 - hEGFR +hEGF 971-1023 + nanobody
    
  • 8hgp - hEGFR + ERBB-2 + proepiregulin – Cryo EM
    
  • 8hgo - hEGFR + ERBB-2 + EGF – Cryo EM
    
  • 3qwq – hEGFR + adnectin
    
  • 5wb8 – hEGFR + epigen
    
  • 5wb7, 7len, 7lfr, 7lfs – hEGFR + epiregulin
    
  • 8hgp – hEGFR + HER2 + epiregulin – Cryo EM
    
  • 8hgo – hEGFR + HER2 + EGF – Cryo EM
    
  • 3u7u – hEGFR + neuregulin
    
  • 4krl, 4krm – EGFR + nanobody – llama
    
  • 3i2t - DmEGFR – Drosophila melanogaster
    
  • 3ltf, 3ltg – DmEGFR + spitz protein
    
• EGFR residues 298-642
  • 8ukw, 8ukx – hEGFR
    
  • 8ukv – hEGFR + nanobody
    
• EGFR residues 335-538
  • 6b3s – hEGFR + antibody
    
• EGFR transmembrane domain (residues 634-677)
  • 2ks1 – hERBB1+hERBB2 transmembrane domains
    
  • 2m0b – hERBB1 – NMR
    
• EGFR kinase domain (residues 682-1022)
  • 7si1 - hEGFR
    
  • 7tvd - hEGFR (mutant)
    
  • 3gt8 – hEGFR +peptide+AMPPNP
    
  • 2gs2, 4tks, 4wrg – hERBB1
    
  • 2gs6 - hERBB1 +peptide
    
  • 5czh, 5czi - hERBB1 (mutant) +peptide
    
  • 5cno, 4zse, 8dsw - hERBB1 (mutant) + ANP
    
  • 2gs7 - hERBB1 +AMPPNP
    
  • 2eb3, 2itn, 2itv, 2itx, 3vjn, 3vjo - hERBB1 (mutant)+AMPPNP
    
  • 2eb2, 2jit, 1m14, 4i1z, 4i20, 3ug1 – hERBB1 (mutant)
    
  • 2rf9, 2rfd, 2rfe, 1xkk, 3lzb, 3poz, 3w32, 3w33, 3w2s, 4jq7, 4jq8, 4jr3, 4jrv, 4li5, 4lrm, 4r5s, 5ug8, 5ugb, 5em8, 5fed, 5cav, 4zau, 6p8q, 6vh4, 6vhn, 6vhp, 7b85, 7kxz, 7u99, 7u9a, 8a27, 8d76, 8f1z, 8hva, 8pnz, 8sc7, 8tjl, 9frd, 9gdv, 9gi9, 9gl9 - hERBB1 + inhibitor
    
  • 2jiu, 2jiv, 2ito, 2itp, 2itq, 2itt, 2itu, 2itw, 2itz, 2j6m, 2j5e, 2j5f, 1m17, 3w2o, 3w2p, 3w2q, 3w2r, 3w2s, 4ll0, 4lqm, 4rj4, 4rj5, 4rj6, 4rj7, 4rj8, 5ug9, 5uga, 5ugc, 5em5, 5em6, 5em7, 5fee, 5feq, 5gnk, 5hcx, 5hcy, 5hcz, 5hg5, 5hg7, 5hg8, 5hg9, 5hib, 5hic, 5j9y, 5j9z, 5jeb, 5d41, 5edp, 5edq, 5edr, 5c8k, 5c8m, 5c8n, 5cal, 5can, 5cao, 5cap, 5caq, 5cas, 5cau, 5cnn, 4wd5, 5xgm, 5xgn, 5xdk, 5xdl, 5x26, 5x27, 5x28, 5x2c, 5x2f, 5x2k, 5uwd, 5gty, 5gtz, 5gmp, 6duk, 6d8e, 5zwj, 5zto, 5y25, 6jrj, 6jrk, 6jrx, 6p1d, 6p1l, 6s89, 6s8a, 6s9b, 6s9c, 6s9d, 6tfu, 6tfv, 6tfw, 6tfy, 6tfz, 6tg0, 6tg1,6v5n, 6v5p, 6v66, 6v6k, 6jwl, 6lub, 6v6o, 6wa2, 6wak, 6wxn, 6xl4, 7a6i, 7a6j, 7a6k, 7aei, 7aem, 7er2, 7k1i, 7ky0, 7ltx, 7oxb, 7u98, 7vra, 7vre, 7zyn, 7zyp, 7zyq, 8a27, 8a2a, 8a2b, 8a2d, 8d73, 8eme, 8fv3, 8fv4, 8gb4, 8hv1, 8hv2, 8hv3, 8hv4, 8hv5, 8hv6, 8hv7, 8hv8, 8hv9, 8hy7, 8kfq, 8po0, 8po1, 8po2, 8po3, 8po4, 8to3, 8to4, 8wd4, 9d3v, 9d3w, 9hbo - hERBB1 (mutant)+inhibitor
    
  • 4g5j, 4i23, 4wkq, 5yu9, 6jz0, 7t4i, 7t4j, 7ukv, 7zym, 8f1h, 8f1x, 8f1y, 8g63 - hERBB1 + cancer drug
    
  • 3ug2, 2ity, 4g5p, 4hjo, 4i22, 4i24, 5y9t, 5x2a, 6jx0, 6jx4, 6jxt, 6lud, 6z4b, 6z4d, 7a2a, 7lgs, 7ukw, 8d73, 8d76, 8h7x - hERBB1 (mutant) + cancer drug
    
  • 7jxi, 7jxk, 7jxl, 7jxm, 7jxp, 7jxq, 7jxw, 7k1h, 7lg8, 8f1w, 8gk5 - hERBB1 (mutant) + cancer drug + inhibitor
    
  • 3b2u - hERBB1 +IMC-11F8 FAB fragment
    
  • 3p0y - hERBB1 + FAB
    
  • 4i21, 4zjv - hERBB1 + ERBB receptor feedback inhibitor 1
    
  • 4r3p, 4r3r - hERBB1 (mutant) + ERBB receptor feedback inhibitor 1 peptide
    
  • 5u8l - hERBB1 + sulfonyl fluoride
    
  • 4riw, 4rix, 4riy - hERBB1 (mutant) + ERBB3
    
  • 3kex – hERBB3
    
• EGFR juxtamembrane domain (residues 669-721)
  • 3gop – hERBB1 kinase and juxtamembrane domains
    
  • 1z9i - hERBB1
    
  • 2m20 – hERBB1 transmembrane and juxtamembrane domains (mutant) - NMR
    
• EGFR fragments
  • 3i7z – hEGFR fragment+hTyrosine phosphatase
    
  • 3g5v, 3g5y, 3g5z, 3g5x – EGFR peptide + mAntibody
    
  • 3ika – hERBB1 (mutant)+inhibitor
    
  • 2rgp – hERBB1+hydrazone
    
  • 3bel – hERBB1+oxime
    
  • 3c09, 5sx4, 5sx5 – hERBB1 domain III+antibody
    
  • 2b2u, 3b2v – hERBB1 fragment+antibody
    
  • 3buo – EGFR 13-mer+hCBL N-terminal
    

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Michal Harel