GABAA receptor

spinqualitylabelsall models Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with pregnanolone (based on 5o8f) scene= Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D GABAA receptors, which are considered ligand-gated ion channels as the binding of GABA results in the opening of ion channels leading to the inhibition of a neuronal signal. Excitatory neurosteroids have excitatory effects on neurotransmission. They act as potent negative allosteric modulators of the GABAA receptor. Major examples include the pregnanes pregnenolone sulfate (PS), epipregnanolone, and isopregnanolone (sepranolone). Pregnenolone alone. Pregnanolone binds beta3-alpha5 GABAA receptor (5o8f). Pregnanolone binding site is situated between 2 monomers. See also: GABA receptor Steroids Neurosteroids Inhibitory neurosteroids Excitatory neurosteroids

GABAA receptor 3D structures

See 5o8f

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Alexander Berchansky, Michal Harel