Inhibitory neurosteroids

spinqualitylabelsall models Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code 5osb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D These neurosteroids exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the GABAA receptor (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects. Major examples include tetrahydrodeoxycorticosterone (THDOC; from 5osb), the androstane 3α-androstanediol, the cholestane cholesterol and the pregnanes pregnanolone (eltanolone), allopregnanolone (3α,5α-THP).

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel