Importin 3D structures

3D structures of importin

Updated on 18-September-2025

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• IPO-α
  • 1ial – mIPO NLS-binding domain – mouse
    
  • 6d7m – mIPO (mutant)
    
  • 4tnm – IPO armadillo repeat domain – Arabidopsis thaliana
    
  • 1bk5 – yIPO NLS-binding domain - yeast
    
  • 7vps – NgIPO ARM domain 75-516 – Nakaceomyces glabratus
    
• IPO-α complex with NLS peptide
  • 1ejl – mIPO NLS-binding domain + SV40 large T antigen
    
  • 1ejy – mIPO NLS-binding domain + nucleoplasmin
    
  • 2ynr – mIPO NLS-binding domain + B54NLS
    
  • 2yns – rIPO NLS-binding domain + B54NLS - rice
    
  • 1bk6 – yIPO NLS-binding domain + SV40 large T antigen
    
  • 1ee4 – yIPO NLS-binding domain (mutant) + c-Myc
    
  • 1ee5 – yIPO NLS-binding domain (mutant) + nucleoplasmin
    
  • 1un0, 2c1t – yIPO NLS-binding domain (mutant) + Nup2
    
  • 5h2x, 5h2w – yIPO NLS-binding domain + ubiquitin-like specific protease
    
  • 4xzr – yIPO NLS-binding domain + HEH1
    
  • 4pvz – yIPO NLS-binding domain + HEH2
    
  • 4rxh – NcIPO NLS-binding domain + SV40 large T antigen – Neurospora crassa
    
  • 5vqi – NcIPO NLS-binding domain + NIT2
    
  • 7vpt – NgIPO ARM domain + Upc2
    
• IPO-α complex with protein
  • 1wa5 – yIPO NLS-binding domain + GTPase Ran + IPO-α re-exporter
    
  • 5t94 – yIPO NLS-binding domain + guanine nucleotide exchange factor
    
  • 5mfm – yIPO NLS-binding domain + YIIIM6AII
    
• IPO-α 1
  • 3wpt, 8fzk – hIPO NLS-binding domain - human
    
  • 4b8j – rIPO
    
  • 6bvt – mIPO NLS-binding domain
    
  • 4u5v, 4u5u, 4u5s, 4u5o, 4u5n, 4u5l, 4u58, 4u54 – mIPO NLS-binding domain + inhibitor
    
  • 8g4j – IPO – guinea pig
    
• IPO-α 1 complex with NLS peptide
  • 2jdq, 4b18 – hIPO NLS-binding domain + telomerase reverse transcriptase
    
  • 4wv6 – hIPO NLS-binding domain + TFIID
    
  • 6bw0 – hIPO NLS-binding domain + Nipa virus peptide
    
  • 6bw1 – hIPO NLS-binding domain + Hendra virus peptide
    
  • 5w4e, 5w4f, 5w4g – hIPO NLS-binding domain + polymerase peptide
    
  • 7n9h – hIPO NLS-binding domain + TDP-43 peptide
    
  • 7cru – hIPO NLS-binding domain + hnRNPK peptide
    
  • 8he3 – hIPO NLS-binding domain + HIF-1 peptide
    
  • 7n8j – hIPO NLS-binding domain + BIMAX peptide
    
  • 5h43 – hIPO NLS-binding domain + histone acetyltransferase KAT8
    
  • 8gcn – hIPO NLS-binding domain + IPO-beta 1 peptide – Cryo EM
    
  • 8gai – IPO NLS-binding domain + BIMAX peptide – guinea pig
    
  • 4mz5, 4mz6 – mIPO NLS-binding domain 70-528 + dUTPase
    
  • 4oih – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1
    
  • 5svz – mIPO NLS-binding domain + TAT NLS motif
    
  • 5wum, 5wun, 5x8n – mIPO NLS-binding domain + Epstein Barr antigen
    
  • 5huw – mIPO NLS-binding domain + HSVI large terminase
    
  • 5huy – mIPO NLS-binding domain + HSMV small terminase
    
  • 5hhg, 5fc8 – mIPO NLS-binding domain + dengue 2 NS5
    
  • 5ekg, 5ekf, 5e6q – mIPO NLS-binding domain + XPG2
    
  • 5d5k – mIPO NLS-binding domain + PARP 2
    
  • 7l04, 8fk3 – mIPO NLS-binding domain + adeno-associated virus
    
  • 5ctt – mIPO NLS-binding domain + SART3/TIP110
    
  • 5b56 – mIPO NLS-binding domain + HIV-1 VPR
    
  • 4zdu – mIPO NLS-binding domain + influenza nucleoprotein
    
  • 4yi0 – mIPO NLS-binding domain + Nup121
    
  • 5klr, 5klt – mIPO NLS-binding domain + NLS
    
  • 5k9s – mIPO NLS-binding domain + HNF-b
    
  • 6iu7, 6iua – mIPO NLS-binding domain + TP53-binding protein
    
  • 5w41 – mIPO NLS-binding domain + Zika virus peptide
    
  • 8fua, 8fuc – mIPO NLS-binding domain + Hendra virus peptide
    
  • 8ech – mIPO NLS-binding domain + tick-bourne encephalitis virus
    
  • 5v5o, 5v5p – mIPO NLS-binding domain + influenza virus peptide
    
  • 5umz – mIPO NLS-binding domain + TNRC6A peptide
    
  • 5u5p, 5u5r, 6wba, 6wbb, 6wbc, 7m60 – mIPO NLS-binding domain + MLH1 peptide
    
  • 5gxw – mIPO NLS-binding domain + NUMA peptide
    
  • 6iw8, 6iwa – mIPO NLS-binding domain + GM130 peptide
    
  • 6k06 – mIPO NLS-binding domain (mutant) + GM130 peptide
    
  • 6mjl – mIPO NLS-binding domain + CHREBP peptide
    
  • 6p6a – mIPO NLS-binding domain + NIT-2 peptide
    
  • 6p6e – mIPO NLS-binding domain + PAC3 peptide
    
  • 7jjm, 7jk7 – mIPO NLS-binding domain + LSD1 peptide
    
  • 7jvo – mIPO NLS-binding domain + ACE2 peptide
    
  • 8he0 – mIPO NLS-binding domain + HIF-1 peptide
    
  • 7rg4, 7rg5 – mIPO NLS-binding domain + p50 peptide
    
  • 6wx7 – mIPO NLS-binding domain + SOX2 peptide
    
  • 8g8q – mIPO NLS-binding domain + monopartite p52 NLS + peptide
    
  • 8g8s – mIPO NLS-binding domain + bipartite p52 NLS peptide
    
  • 9cl8, 9cle, 9clf, 9clg – mIPO NLS-binding domain + zero net charge NLS peptide
    
  • 9y0r – mIPO NLS-binding domain + ATF2 peptide
    
  • 5fc8, 5hhg, 8vpr, 8vpu – mIPO NLS-binding domain + dengue virus peptide
    
  • 4b8o – rIPO NLS-binding domain + SV40
    
  • 4b8p – rIPO NLS-binding domain + A89
    
  • 4bpl – rIPO NLS-binding domain + nucleoplasmin
    
  • 4bqk – rIPO NLS-binding domain + VirD2
    
• IPO-α 1 complex with protein
  • 2jdq – hIPO NLS-binding domain + polymerase basic protein 2 C terminal
    
  • 3tj3 – hIPO NLS-binding domain + Nup50 N terminal
    
  • 2jdq – hIPO NLS-binding domain + telomerase reverse transcriptase peptide
    
  • 4uaf – mIPO NLS-binding domain + influenza RNA polymerase
    
  • 8sg7, 9cft – mIPO NLS-binding domain + adeno-associated virus VP1
    
• IPO-α 2
  • 3tpo – mIPO
    
  • 1iq1 – mIPO NLS-binding + autoinhibitory peptide domains
    
  • 4e4v – hIPO NLS-binding domain (mutant)
    
• IPO-α 2 complex with NLS peptide
  • 1pjm – mIPO NLS-binding domain + retinoblastoma-associated protein
    
  • 1pjn – mIPO NLS-binding domain + histone-binding protein N1/N2
    
  • 1q1s, 1q1t – mIPO NLS-binding domain + SV40 large T antigen
    
  • 1y2a, 3q5u – mIPO NLS-binding domain + phospholipid scramblase
    
  • 2c1m – mIPO NLS-binding domain + Nup50
    
  • 7leq – mIPO NLS-binding domain + p50
    
  • 7leu – mIPO NLS-binding domain + p65
    
  • 3btr – mIPO NLS-binding domain + androgen receptor
    
  • 3knd – mIPO NLS-binding domain + targeting protein for KXLP2
    
  • 3l3q – mIPO NLS-binding domain + library peptide
    
  • 3oqs – mIPO NLS-binding domain + CLIC4
    
  • 3rz9 – mIPO NLS-binding domain + KU80
    
  • 3rzx – mIPO NLS-binding domain + KU70
    
  • 3tpm – mIPO NLS-binding domain + MAL
    
  • 3ve6 – mIPO NLS-binding domain + Venezuelan equine encephalitis virus
    
  • 8f2q – mIPO NLS-binding domain + parvovirus
    
  • 8q8k, 8sud, 8tuq, 8tur, 8tus, 8tut, 8tuu, 8tuv – mIPO NLS-binding domain + polyomavirus peptide
    
  • 8sv0, 8u36 – mIPO NLS-binding domain + siadenovirus peptide
    
  • 8g8r – mIPO NLS-binding domain + RELB peptide
    
  • 3uvu – mIPO NLS-binding domain + flap endonuclease
    
  • 3ukw, 3ukx – mIPO NLS-binding domain + BIMAX
    
  • 3uky, 3ukz, 3ul0 – mIPO NLS-binding domain + nuclear CAP-binding protein
    
  • 3ul1 – mIPO NLS-binding domain + nucleoplasmin
    
  • 4htv – mIPO NLS-binding domain + capsid protein
    
  • 4ba3 – mIPO NLS-binding domain + A89NLS
    
  • 3zio, 3zip, 3ziq, 3zir – mIPO NLS-binding domain + minor site-specific NLS
    
  • 3zin – mIPO NLS-binding domain + nucleolar RNA helicase
    
  • 7jjm – mIPO + LSD1 peptide
    
• IPO-α 2 complex with protein
  • 3fex, 3fey – mIPO NLS-binding domain + nuclear CAP-binding protein
    
  • 7rfx, 7rfz, 7rg0, 7rg1, 7rg2, 7rg3, 7rg6 – mIPO + ORF4b
    
• IPO-α 3
  • 6bvz – hIPO NLS-binding domain
    
  • 4uae – hIPO NLS-binding domain + influenza RNA polymerase
    
  • 8qxx – hIPO NLS-binding domain + Herpes DNA polymerase processivity factor peptide
    
  • 8qxw – hIPO NLS-binding domain + cytomegalovirus DNA polymerase processivity factor peptide
    
  • 6bw9, 6bwa, 6bwb – hIPO NLS-binding domain + Hendra virus peptide
    
  • 6bvv – hIPO NLS-binding domain + Nipa virus peptide
    
  • 5xzx – hIPO NLS-binding domain + RAN-binding protein peptide
    
  • 8hkw – hIPO NLS-binding domain + 53BP1 peptide
    
  • 5tbk – hIPO NLS-binding domain + regulator of chromosome condensation
    
  • 7rfy – hIPO + ORF4b
    
  • 6wx8 – hIPO + SOX2
    
  • 7lfc – hIPO + p50 NLS
    
  • 7lf4 – hIPO + p50 NLS + p65 NLS
    
  • 8fub – hIPO NLS-binding domain + Hendra virus peptide
    
  • 7jjl – hIPO + LSD1 peptide
    
  • 8fzm – mIPO NLS-binding domain + BIMAX
    
  • 7let – mIPO + p50 NLS + p65 NLS
    
• IPO-α 5
  • 6wx9 – hIPO + SOX2
    
• IPO-α 6
  • 4u2x – hIPO C terminal + ebola VP24
    
• IPO-α 7
  • 7rht – hIPO
    
  • 4uad – hIPO NLS-binding domain + influenza RNA polymerase
    
• IPO-β
  • 4xri, 4xrk – IPO – Chaetomium thermophilum
    
• IPO-β 1 (karyopherin β 1)
  • 3nd2 – yIPO
    
  • 1gcj – mIPO N terminal
    
• IPO-β 1 complex with protein
  • 1qgx, 1qgk – hIPO + IPO-α 2 IBB domain
    
  • 1ibr – hIPO + GTPase Ran
    
  • 6n88, 6n89 – hIPO + H1.0 – Cryo EM
    
  • 9b4y – hIPO + IPO beta 1 peptide – Cryo EM
    
  • 1f59, 1o6p, 1o6o – hIPO + FXFG nucleoporin repeats
    
  • 1m5n – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide
    
  • 2p8q, 2q5d, 2qna, 3lww – hIPO + RNA U transporter N terminal
    
  • 1qgr, 3w5k – hIPO + zinc finger protein SNAI1
    
  • 1ukl – mIPO + SREBP-2
    
  • 2bku, 3ea5 – yIPO + GTPase Ran
    
  • 5owu – yIPO + Nup1
    
• IPO-β 2 (Transportin 1)
  • 2z5j, 2qmr – hIPO
    
• IPO-β 2 complex with protein
  • 2h4m, 2ot8, 2z5n – hIPO + hnRNP peptide
    
  • 2z5k, 2z5m – hIPO + nuclear RNA export factor peptide
    
  • 2z5o – hIPO + JKTBP peptide
    
  • 4fdd, 4jlq, 4oo6 – hIPO + RNA binding protein peptide
    
  • 5yvg, 5yvh – hIPO + FUS
    
  • 5vyh, 5vyi – hIPO + FUS peptide
    
  • 4fq3 – hIPO + FUS peptide
    
  • 5tqc – hIPO + RPL4 peptide
    
  • 5j3v – hIPO + histone H3 peptide
    
  • 8sgh – hIPO NLS-binding domain + HNRNPH2
    
• IPO-β 3 (Karyopherin β 3)
  • 3w3t – yIPO
    
  • 3w3u, 3w3v – yIPO (mutant)
    
  • 3w3w – yIPO + STE12P
    
  • 3w3x – yIPO + PHO4
    
  • 3w3y – yIPO + Nup53P
    
  • 3w3z – yIPO + RANGTP
    
  • 5h2v – yIPO + ubiquitin-like specific protease
    
  • 4zj7 – yIPO + CDC14
    
• IPO-β 5 (Karyopherin β 5)
  • 6aho – yIPO
    
  • 8h5b – yIPO + TATA box – Cryo EM
    
  • 8f0x – yIPO + histone H2A.2 + H2B.2 – Cryo EM
    
  • 8f19 – yIPO + RANGTP – Cryo EM
    
• IPO-4
  • 8dyo – hIPO + RanGTP – Cryo EM
    
  • 7unk – hIPO + H3 + H4 + ASF1 – Cryo EM
    
• IPO-4B
  • 5xah – hIPO residues 668-1081
    
  • 5xbk – hIPO residues 668-1081 + histone H3 peptide
    
• IPO-5
  • 6xte, 6xu2 – hIPO + antipain peptide
    
  • 9im6 – mIPO NLS-binding domain + RanBP5 peptide – Cryo EM
    
• IPO-7
  • 6n88 – IPO + hIPO-90 + histone H1.0 – frog – Cryo EM
    
• IPO-9
  • 6n1z – hIPO + histone H2A + histone H2B
    
  • 8f7a – hIPO NLS-binding domain + RanGTP – Cryo EM
    
• IPO-12 (Transportin-3)
  • 4c0p – hIPO
    
  • 4c0o – hIPO + serine/arginine-rich splicing factor
    
  • 4c0q, 4ol0 – hIPO + GTPase Ran
    
  • 6gx9 – hIPO + CPSF 68
    
  • 8cmk – hIPO + CIRBP
    
• IPO-13 (karyopherin 13)
  • 2x19 – hIPO + GTPase Ran
    
  • 2xwu – hIPO + UBC9
    
  • 3zjy – hIPO + GTPase Ran + EIF-1A
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman