Mitogen-activated protein kinase kinase kinase 3D structures

Mitogen-activated protein kinase kinase kinase

Updated on 31-December-2025

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• MAP3K1; Domains – kinase 10-307; catalytic 325-619; SH3-binding 465-480; TOG 648-867
  • 6nfy, 6nfz - hMAP3K1 kinase domain + cancer drug - human
    
  • 6ng0 - hMAP3K1 kinase domain (mutant) + cancer drug
    
  • 6nfz - hMAP3K1 kinase domain + inhibitor
    
  • 8yp4 - hMAP3K1 kinase domain (mutant) + inhibitor
    
  • 6nyb - hMAP3K1 kinase domain (mutant) + B-raf + 14-3-3 protein zeta – Cryo EM
    
  • 6whb - hMAP3K1 TOG domain + cancer drug
    
  • 1uti – MAP3K1 SH3-binding domain +GRB2-related adaptor protein 2 – mouse
• MAP3K2
  • 2cu1 – hMAP3K2 PB1 domain (mutant) - NMR
  • 5uoj, 2o2v – hMAP3K2+hMAP3K5
  • 2npt - hMAP3K2 PHOX domain + hMAP2K5 PHOX domain
  • 9p6a - hMAP3K2 catalytic domain + drug
    
• MAP3K3
  • 2c60 – hMAP3K3 PHOX domain
  • 2jrh - hMAP3K3 PB1 domain
  • 2pph - hMAP3K3 PB1 domain – NMR
• MAP3K5 (Ask1; Apoptosis signal-regulating kinase 1)
  • 2clq – hMAP3K5
  • 8qgy – hMAP3K5 – Cryo EM
  • 6oyt, 6vre, 6xih, 7mu6, 7mu7 - hMAP3K5 + inhibitor
    
  • 4bf2, 4bhn, 4bib, 4bic, 4bid, 4bie, 6e2m, 6e2n, 6e2o, 6oyw - hMAP3K5 (mutant) + inhibitor
    
• MAP3K7 or TAK1
  • 2eva – hMAP3K7/MAP3K7-interacting protein 1
  • 2y1y, 4gs4, 4l3p, 4l52, 4l53, 4o91, 5gjd, 5gjf, 5gjg, 5e7r, 5jga, 5jgb, 5jgd, 7nth - hMAP3K7/MAP3K7-interacting protein 1 + inhibitor
    
  • 8gw3 - hMAP3K7/TGF-beta-activated kinase 1 and MAP3K7-interacting protein 1
    
  • 9fpd - hMAP3K7/TGF-beta-activated kinase 1 and MAP3K7-interacting protein 1 + inhibitor
    
• MAP3K9
  • 3dtc - hMAP3K9 (mutant) + inhibitor
• MAP3K10
  • 2rf0 - hMAP3K10 SH3 domain – NMR
• MAP3K11
  • 6cq7 - hMAP3K11 SH3 domain/huntington fusion peptide
    
• MAP3K12 kinase domain 115-402; or DLK or dual leucine zipper bearing kinase
  • 5cen - hMAP3K12
    
  • 5ceo, 8deg, 8our, 8ous, 8out, 9cdx, 9cdy - hMAP3K12 + inhibitor
    
• MAP3K14 kinase domain 343-686 or NIK or NF-kappa-beta-inducing kinase
  • 8yhw - hMAP3K14 + ATP-γ-S
    
  • 4dn5 - hMAP3K14 (mutant) + ATP-γ-S
    
  • 4idt, 4idv, 6wpp, 6z1q, 6z1t - hMAP3K14 + inhibitor
    
  • 6g4y, 6g4z, 6myn, 7szr - mMAP3K14 + inhibitor
    
• MAP3K15
  • 6v0m - hMAP3K15 residues 1241-1308
    
• MAP3K20
  • 9rsx - hMAP3K20 + plasminogenactivator inhibitor + ribosomal protein S3 + receptor of activated protein C kinase – Cryo EM
    
• MAP3K MLT or ZAK
  • 6jut, 6juu, 7yaw, 7yaz - hMAP3K + inhibitor
    

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Michal Harel, Jaime Prilusky