User contributions for Mari Debbarma

30 November 2025

• 18:2418:24, 30 November 2025 diff hist +6 Short transient receptor potential channel final changes
• 18:2318:23, 30 November 2025 diff hist +98 Short transient receptor potential channel added the rest of the images
• 18:2118:21, 30 November 2025 diff hist +147 N File:Calcium Permeability (K639 in S6) .png The positively charged K639 from TRPC1 creates an electropositive environment deep in the pore that repels positively charged $\text{Ca}^{2+}$ ions current
• 18:1918:19, 30 November 2025 diff hist +157 N File:Selectivity Filter Narrowing (L601) .png L601 (TRPC1) physically projects into the pore, driven by a longer selectivity filter loop, narrowing the ion pathway and altering monovalent ion preference. current
• 18:1718:17, 30 November 2025 diff hist −184 Short transient receptor potential channel changed the picture again, as the initial one failed
• 18:1318:13, 30 November 2025 diff hist +236 Short transient receptor potential channel added a png in structures
• 18:1018:10, 30 November 2025 diff hist +54 N File:Asymmetry (TRPC1 TRPC4 Stoichiometry) .png TRPC1 changing the symmetry when incorporated in TRPC4 current
• 18:0218:02, 30 November 2025 diff hist −1,630 Short transient receptor potential channel removed the codes
• 17:5617:56, 30 November 2025 diff hist +131 N File:Calcium Permeability (K639 in S6).pse $\text{K639}$ on TRPC1 acts as an electrostatic barrier that actively excludes $\text{Ca}^{2+}$ from the central conduction pathway current
• 17:5417:54, 30 November 2025 diff hist +234 N File:Selectivity Filter Narrowing (L601).pse The extra length of the TRPC1 loop, anchored by the protruding $\text{L601}$ side chain, creates an asymmetric constriction in the selectivity filter, which is the mechanism behind the channel's shift toward monovalent ion selectivity current
• 17:5217:52, 30 November 2025 diff hist +160 N File:1. Asymmetry (TRPC1 TRPC4 Stoichiometry).pse The incorporation of the single TRPC1 subunit is the structural determinant that converts a symmetric pore into an asymmetric one, thereby changing its function current
• 14:1814:18, 30 November 2025 diff hist −28 Short transient receptor potential channel new codes for the images, manual
• 14:1214:12, 30 November 2025 diff hist +1,078 Short transient receptor potential channel changed 3D picture codes
• 14:0614:06, 30 November 2025 diff hist +5 Short transient receptor potential channel No edit summary
• 13:5513:55, 30 November 2025 diff hist +5,842 Short transient receptor potential channel structures highlight and 3D pictures included
• 12:3912:39, 30 November 2025 diff hist +45 N Sandbox TRPC1 TRPC4 8WPL Sandbox TRPC1 TRPC4 8WPL moved to TRPC1 TRPC4 8WPL BI3323 Aug2025 current
• 12:3912:39, 30 November 2025 diff hist 0 m Short transient receptor potential channel Sandbox TRPC1 TRPC4 8WPL moved to TRPC1 TRPC4 8WPL BI3323 Aug2025

29 November 2025

• 01:3901:39, 29 November 2025 diff hist +2,164 N Short transient receptor potential channel Initial page creation for Sandbox_TRPC1_TRPC4_8PWL