Uploads by Mari Debbarma
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This special page shows all uploaded files.
| Date | Name | Thumbnail | Size | Description | Versions |
|---|---|---|---|---|---|
| 18:21, 30 November 2025 | Calcium Permeability (K639 in S6) .png (file) | _.png) |
736 KB | The positively charged K639 from TRPC1 creates an electropositive environment deep in the pore that repels positively charged $\text{Ca}^{2+}$ ions | 1 |
| 18:19, 30 November 2025 | Selectivity Filter Narrowing (L601) .png (file) | _.png) |
553 KB | L601 (TRPC1) physically projects into the pore, driven by a longer selectivity filter loop, narrowing the ion pathway and altering monovalent ion preference. | 1 |
| 18:10, 30 November 2025 | Asymmetry (TRPC1 TRPC4 Stoichiometry) .png (file) | _.png) |
408 KB | TRPC1 changing the symmetry when incorporated in TRPC4 | 1 |
| 17:56, 30 November 2025 | Calcium Permeability (K639 in S6).pse (file) |  |
6.39 MB | $\text{K639}$ on TRPC1 acts as an electrostatic barrier that actively excludes $\text{Ca}^{2+}$ from the central conduction pathway | 1 |
| 17:54, 30 November 2025 | Selectivity Filter Narrowing (L601).pse (file) | |
6.38 MB | The extra length of the TRPC1 loop, anchored by the protruding $\text{L601}$ side chain, creates an asymmetric constriction in the selectivity filter, which is the mechanism behind the channel's shift toward monovalent ion selectivity | 1 |
| 17:52, 30 November 2025 | 1. Asymmetry (TRPC1 TRPC4 Stoichiometry).pse (file) | |
6.3 MB | The incorporation of the single TRPC1 subunit is the structural determinant that converts a symmetric pore into an asymmetric one, thereby changing its function | 1 |
