Tubulin tyrosine ligase

spinqualitylabelsall models Tubulin tyrosine ligase (cyan) complex withα-tubulin (grey and pink), β-tubulin (green and yellow), stathmin (magenta), MES, GTP, Ca+2, Cl- and Mg+2 ions (PDB code 4iij) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Tubulin tyrosine ligase (TTL) adds tyrosine in an ATP-dependent reaction to the C-terminal of a detyrosinated a-tubulin. The detyrosination of α-tubulin is a posttranslational modification which exposes glutamate in the new tubulin C-terminal. The detyrosinated α-tubulin forms Glu-microtubules. The complex of TTL and tubulin contains Stathmin (STM) - another tubulin-binding protein. Disease Mutated TTL causes morphogenic abnormalities and cancer. There is a loss of TTL activity during tumor growth. Structural highlights Tubulin tyrosine ligase complex with α-tubulin (2 chains), β-tubulin (2 chains), and stathmin. TTL structure is composed of N-terminal, central and C-terminal domains. TTL interacts with α- and β-tubulin via 3 loops and one helix terminal. 3D Structures of tubulin tyrosine ligase Tubulin tyrosine ligase 3D structures

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